Novel One‐Pot Synthesis of Functionalized Quinolines from Isocyanides, Aniline, and Acetylene Dicarboxylate via Cu‐Catalyzed Intramolecular C─H Activation Reactions

The one‐pot synthesis of a novel class of substituted quinoline derivatives with good yields is achieved via the Cu‐catalyzed intramolecular C─H activation reaction between isocyanides, aniline, and acetylene dicarboxylate in MeCN at room temperature. The existence of one‐pot conditions, availabilit...

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Bibliographic Details
Published inJournal of heterocyclic chemistry Vol. 56; no. 4; pp. 1254 - 1259
Main Authors Nematpour, Manijeh, Rezaee, Elham, Jahani, Mehdi, Tabatabai, Sayyed Abbas
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc 01.04.2019
Subjects
Acetylene
Activation
Aniline
Chemical reactions
Chemical synthesis
Column chromatography
NMR
Nuclear magnetic resonance
Organic compounds
Quinoline
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Summary:The one‐pot synthesis of a novel class of substituted quinoline derivatives with good yields is achieved via the Cu‐catalyzed intramolecular C─H activation reaction between isocyanides, aniline, and acetylene dicarboxylate in MeCN at room temperature. The existence of one‐pot conditions, availability of a starting material‐catalyst, the absence of column chromatography, and a high yield of products are among the advantages of this method. The structures are confirmed spectroscopically (1H NMR and 13C NMR, IR, and EI‐MS) and through elemental analyses.
ISSN:0022-152X
1943-5193
DOI:10.1002/jhet.3477