Fundamental studies on the cortical infarction model induced by permanent middle cerebral artery occlusion in rats

• Published in: Japanese Journal of Pharmacology Vol. 73; no. suppl.1; p. 211
• Main Authors: Furukawa, Takeshi, Ova, Shuji, Anekawa, Rie, Hachitanda, Mami, Jin, Jingii, Susumu, Teruo
• Format: Journal Article
• Language: English; Japanese
• Published: The Japanese Pharmacological Society 1997
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)45345-6

Although permanent middle cerebral artery (MCA) occlusion in rats is widely used for focal cerebral ischemia, the infarction figure varies with the site of MCA occlusion. In this study, we attempted to establish a method for creating the limited cortex infarction by distal MCA occlusion in SHR rats. Also, we assessed the size of infarction 24 hours after MCA occlusion and observed the behavioral changes during 5 weeks. The limited cortex infarction was confirmed 24 hours after MCA occlusion at the outside of olfactory tract (distal). MK-801 significantly inhibited the formation of infarction in this model, but could not improve the striatum infarction. On the other hand, in the cortex limited infarction model, sensorimotor impairments were obviously recognized, and these impairments were recovered gradually after 3 weeks. But in the striatum infarction model, sensorimotor impairments did not recover completely until 5 weeks after surgery. These results suggested that cortex limited infarction model may be useful for drug evaluation as acute model and to assess sensorimotor function as chronic model.