Measurement of circular dichroism and structural chemical research of d(CG)6 and d(TA)6

It was known that d(CG)6 became left-handed Z-DNA by a theoretical calculation. We carried out a CD measurement of d(CG)6 at room temperature. B-Z transition was occurred when I raised the concentration of Mg salt. In addition, I confirmed that the Mg salt concentration caused B-Z transition by the...

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Published inNucleic Acids Symposium Series Vol. 50; no. 1; pp. 227 - 228
Main Authors Tozuka, Yoshitaka, Yoshikawa, Yuki, Ohishi, Hirofumi, Kobayashi, Yuji, Da-Yang, Zhou, Nakatani, Kazuhiko
Format Journal Article
LanguageEnglish
Published Oxford University Press 01.11.2006
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Summary:It was known that d(CG)6 became left-handed Z-DNA by a theoretical calculation. We carried out a CD measurement of d(CG)6 at room temperature. B-Z transition was occurred when I raised the concentration of Mg salt. In addition, I confirmed that the Mg salt concentration caused B-Z transition by the lower concentration under the existence of cobalt hexamine. Structure of d(TA)6 is not known. We performed the CD measurement of d(TA)6 at low temperature. Structure changed from B type when I raised the Mg salt concentration in an existence of cobalt hexamine. I am examining structure now.
ISSN:0261-3166
1746-8272
DOI:10.1093/nass/nrl113