Neuron–Muscle Interfaces: Matrix Topography Regulates Synaptic Transmission at the Neuromuscular Junction (Adv. Sci. 6/2019)

• Published in: Advanced science Vol. 6; no. 6
• Main Authors: Ko, Eunkyung, Yu, Seung Jung, Pagan‐Diaz, Gelson J., Mahmassani, Ziad, Boppart, Marni D., Im, Sung Gap, Bashir, Rashid, Kong, Hyunjoon
• Format: Journal Article
• Language: English
• Published: Weinheim John Wiley & Sons, Inc 20.03.2019; John Wiley and Sons Inc
• Subjects: acetylcholine receptors; Inside Front Cover; motor neurons; myotubes; neural innervation; neuromuscular junctions

In article number 1801521, Hyunjoon Kong and co‐workers demonstrate that substrate topography regulates neural innervation by enhancing maturity of the myotubes. Neural stem cells are differentiated on the myotubes, formed on grooved substrates. The motor neurons innervate more actively to the matur...