Neuron–Muscle Interfaces: Matrix Topography Regulates Synaptic Transmission at the Neuromuscular Junction (Adv. Sci. 6/2019)

In article number 1801521, Hyunjoon Kong and co‐workers demonstrate that substrate topography regulates neural innervation by enhancing maturity of the myotubes. Neural stem cells are differentiated on the myotubes, formed on grooved substrates. The motor neurons innervate more actively to the matur...

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Bibliographic Details
Published inAdvanced science Vol. 6; no. 6
Main Authors Ko, Eunkyung, Yu, Seung Jung, Pagan‐Diaz, Gelson J., Mahmassani, Ziad, Boppart, Marni D., Im, Sung Gap, Bashir, Rashid, Kong, Hyunjoon
Format Journal Article
LanguageEnglish
Published Weinheim John Wiley & Sons, Inc 20.03.2019
John Wiley and Sons Inc
Subjects
acetylcholine receptors
Inside Front Cover
motor neurons
myotubes
neural innervation
neuromuscular junctions
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Summary:In article number 1801521, Hyunjoon Kong and co‐workers demonstrate that substrate topography regulates neural innervation by enhancing maturity of the myotubes. Neural stem cells are differentiated on the myotubes, formed on grooved substrates. The motor neurons innervate more actively to the mature myotubes formed on the 1600 nm groove width. Accordingly, those myotubes respond more rapidly to neurotransmitter and neuromuscular antagonists. The results of this study will be useful for improving the quality of engineered muscle used in applications such as drug screening, regeneration therapies, and biological machinery assembly.
ISSN:2198-3844
2198-3844
DOI:10.1002/advs.201970032