Effect of KW-5092, a gastroprokinetic agent, on the peristalsis in the isolated guinea pig ileum

• Published in: Japanese Journal of Pharmacology Vol. 73; no. suppl.1; p. 222
• Main Authors: Suzuki, Mayumi, Kishibayashi, Nobuyuki, Yokoyama, Toshihide, Karasawa, Akira
• Format: Journal Article
• Language: English; Japanese
• Published: The Japanese Pharmacological Society 1997
• ISSN: 0021-5198; 1347-3506
• DOI: 10.1016/S0021-5198(19)45391-2

KW-5092 is a newly synthesized gastroprokinetic agent which enhances the release of acetylcholine and inhibits acetylcholine esterase. The previous in vivo study demonstrated that KW-5092 stimulates the small intestinal propulsion in the conscious rat. In the present study, we investigated the effects of KW-5092 and some other gastroprokinetic agents on the peristalsis of the small intestine in vitro. The ileum of guinea pig was excised and mounted in a water bath, and lumminally perfused with Tyrode solution from the oral end. The pressure of the solution eliminated from the anal end was recorded. Drugs were administered directly to the bath. KW-5092 (0.1-3μM) concentration-dependently increased the frequency of the peristaltic wave without changing the amplitude. This effect of KW-5092 was inhibited by atropine. Neostigmine at 0.1μM also increased the frequency, while domperidone (0.01-3μM) had no effect on the peristalsis. These results suggest that KW-5092 enhances peristalsis in the small intestine via inhibiting the activity of acethylcholine esterase.