Apolipoprotein E genotype has no effect on the free intracellular Ca2+ concentration of platelets from Alzheimer's disease patients

The free intracellular Ca2+ concentration [Ca2+]i of platelets was investigated in Alzheimer's disease (AD) patients and age-matched control subjects with distinct Apo E genotypes. No significant differences were found between the Apo E genotype and the [Ca2+]i levels of platelets (basal and al...

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Bibliographic Details
Published inInternational journal of molecular medicine Vol. 3; no. 4; p. 431
Main Authors Fernandes, M A, Proença, M T, Nogueira, A J, Oliveira, L M, Santiago, B, Santana, I, Oliveira, C R
Format Journal Article
LanguageEnglish
Published Greece 01.04.1999
Subjects
Adult
Aged
Aged, 80 and over
Alleles
Alzheimer Disease - blood
Alzheimer Disease - genetics
Analysis of Variance
Apolipoproteins E - genetics
Blood Platelets - drug effects
Blood Platelets - metabolism
Calcium - metabolism
Female
Humans
Male
Middle Aged
Thrombin - metabolism
Thrombin - pharmacology
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Summary:The free intracellular Ca2+ concentration [Ca2+]i of platelets was investigated in Alzheimer's disease (AD) patients and age-matched control subjects with distinct Apo E genotypes. No significant differences were found between the Apo E genotype and the [Ca2+]i levels of platelets (basal and alpha-thrombin stimulated) from AD patients and age-matched control subjects, suggesting that [Ca2+]i homeostasis of platelets from AD patients is independent of the Apo E genotype. The results are discussed in terms of involvement of Apo E and [Ca2+]i changes in the etiopathogenesis of AD.
ISSN:1107-3756
DOI:10.3892/ijmm.3.4.431