Iron-catalyzed one-pot cyclization and amination of 2-alkynylthioanisoles using nitrosobenzenes as the amine source
A direct strategy for the synthesis of 3-phenylaminobenzothiophene via iron-catalyzed cyclization of 2-alkynylthioanisoles and nitrosoarenes is presented in this work. This method realizes the construction and amination of the benzothiophene ring in which nitrosoarenes serve as the amine source. Var...
Saved in:
Published in | ORGANIC CHEMISTRY FRONTIERS Vol. 9; no. 15; pp. 4085 - 4090 |
---|---|
Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
CAMBRIDGE
Royal Soc Chemistry
26.07.2022
Royal Society of Chemistry |
Subjects | |
Online Access | Get full text |
Cover
Loading…
Summary: | A direct strategy for the synthesis of 3-phenylaminobenzothiophene via iron-catalyzed cyclization of 2-alkynylthioanisoles and nitrosoarenes is presented in this work. This method realizes the construction and amination of the benzothiophene ring in which nitrosoarenes serve as the amine source. Various functional groups are tolerated in this reaction and the desired products are obtained in moderate yields. |
---|---|
ISSN: | 2052-4129 2052-4110 2052-4110 |
DOI: | 10.1039/d2qo00535b |