ATTEMPTED ACCELERATION OF THE ONSET OF ACTION OF PANCURONIUM
The study was designed to determine whether the onset of action of pancuronium in infants and children could be accelerated by its administration in divided doses. Sixty paediatric patients (0–1 yr (n = 20); 1–3 yr (n = 20); 3–10 yr (n = 20)) were studied during nitrous oxide-oxygenhalothane anaesth...
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| Published in | British journal of anaesthesia : BJA Vol. 57; no. 12; pp. 1204 - 1208 |
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| Main Authors | , , |
| Format | Journal Article |
| Language | English |
| Published |
Elsevier Ltd
01.12.1985
Oxford University Press |
| Online Access | Get full text |
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| Summary: | The study was designed to determine whether the onset of action of pancuronium in infants and children could be accelerated by its administration in divided doses. Sixty paediatric patients (0–1 yr (n = 20); 1–3 yr (n = 20); 3–10 yr (n = 20)) were studied during nitrous oxide-oxygenhalothane anaesthesia using train-of-four stimulation, and the results were compared with data obtained previously in adults. The time to onset correlated with the patient’s age, and an additional, small acceleration was produced following divided doses which did not alter the duration or pattern of neuromuscular blockade. It was concluded that, in children, divided doses of pancuronium are unlikely to offer important clinical advantages. |
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| Bibliography: | ArticleID:57.12.1204 Correspondence to D. R. B. ark:/67375/HXZ-DC58P7V0-N Presented at the Annual Meeting of American Society of Anesthesiologists at New Orleans, 1984. istex:8F39531A31894C5E00CDC545558EECEEA4C23D1D |
| ISSN: | 0007-0912 1471-6771 |
| DOI: | 10.1093/bja/57.12.1204 |