The association of serum dephosphorylated-uncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) as a marker of vascular vitamin K status with allograft function in kidney transplant recipients

• Published in: Journal of nephropathology Vol. 9; no. 3; p. e24
• Main Authors: Ebrahimzadeh Attari, Vahideh, Shahvegharasl, Zahra, Fathalizadeh, Pouya, Pourasghary, Sajjad, Mohajel Shoja, Mohammadali, Niknafs, Bahram, Ardalan, Mohammad Reza
• Format: Journal Article
• Language: English
• Published: Society of Diabetic Nephropathy Prevention 01.07.2020
• Subjects: cardiovascular disease; chronic kidney disease; end-stage renal disease; kidney function; kidney transplant; matrix gla protein; vascular calcification; vitamin k
• ISSN: 2251-8363; 2251-8819
• DOI: 10.34172/jnp.2020.24

Introduction : Kidney transplantation has considerably increased the survival and life quality of patients with end-stage renal disease. Objectives : The current study was designed to investigate the circulating level of dephosphorylateduncarboxylated matrix gamma carboxyglutamate protein (dp-ucMGP) as a marker of vitamin K status and vascular calcification in kidney transplant recipients as well as its association with the allograft function. Patients and Methods : In this cross-sectional study, 90 eligible kidney transplant recipients were evaluated in the post-transplant phase (about 6-12 months after kidney transplantation). The serum levels of dp-ucMGP, urea, creatinine and other biochemical indices were determined. Results : The mean serum level of dp-ucMGP was 3.78±3.79 µg/L. Most of the participants (80%) had a normal range of serum dp-ucMGP (<4 µg/L). However, 10 % had high serum dp-ucMGP (>12 µg/L). Serum dp-ucMGP did not have any statistical significant association with serum urea, creatinine and kidney function (P>0.05). Conclusion : Further epidemiologic studies are needed to assess the time trends of dp-ucMGP after renal transplant and its relation to kidney function, since high serum level of dp-ucMGP may make kidney transplant recipients prone to various cardiovascular disease (CVD) and transplant rejection.