Human In vivo Radiation-Induced Biomarkers

Abstract After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarra...

Full description

Saved in:
Bibliographic Details
Published inCancer research (Chicago, Ill.) Vol. 64; no. 18; pp. 6368 - 6371
Main Authors Amundson, Sally A., Grace, Marcy B., McLeland, Christopher B., Epperly, Michael W., Yeager, Andrew, Zhan, Qimin, Greenberger, Joel S., Fornace, Albert J.
Format Journal Article
LanguageEnglish
Published 15.09.2004
Online AccessGet full text

Cover

More Information
Summary:Abstract After initially identifying potential biomarkers of radiation exposure through microarray studies of ex vivo irradiated human peripheral white blood cells, we have now measured the in vivo responses of several of these biomarker genes in patients undergoing total body irradiation. Microarray analysis has identified additional in vivo radiation-responsive genes, although the general in vivo patterns of stress-gene induction appear similar to those obtained from ex vivo white blood cell experiments. Additional studies may reveal correlations between responses and either diagnosis or prognosis, and such in vivo validation marks an important step in the development of potentially informative radiation exposure biomarkers.
ISSN:0008-5472
1538-7445
DOI:10.1158/0008-5472.CAN-04-1883