Ballantyne syndrome: is placental ischemia the etiology?

Ballantyne syndrome is a condition in which the gravid patient essentially "mirrors" the in utero state of the hydropic fetus. The exact pathophysiological mechanism, however, is unclear. At 25 weeks gestation, a 28-year-old G3P2 presented with acute onset lower extremity edema, hyperurice...

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Bibliographic Details
Published inThe Journal of maternal-fetal medicine Vol. 7; no. 5; p. 227
Main Authors Gherman, R B, Incerpi, M H, Wing, D A, Goodwin, T M
Format Journal Article
LanguageEnglish
Published United States 01.09.1998
Subjects
Adult
Anemia - etiology
Diuresis
Edema - etiology
Fatal Outcome
Female
Gestational Age
Humans
Hydrops Fetalis - etiology
Hypertension - etiology
Infant, Newborn
Ischemia - complications
Male
Obstetric Labor, Premature - etiology
Placenta - blood supply
Polyhydramnios - etiology
Pregnancy
Pruritus - etiology
Syndrome
Uric Acid - blood
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Summary:Ballantyne syndrome is a condition in which the gravid patient essentially "mirrors" the in utero state of the hydropic fetus. The exact pathophysiological mechanism, however, is unclear. At 25 weeks gestation, a 28-year-old G3P2 presented with acute onset lower extremity edema, hyperuricemia, polyhydramnios, generalized pruritus, hemodilutional anemia, and pre-term labor. The human chorionic gonadotrophin (hCG) level was markedly elevated, at 570,020 mIU/ml. Postpartum, she developed a pre-eclampsia-like syndrome with oliguria and pulmonary effusions. Associated placental findings included a 8 x 7 x 7 cm chorangioma. Underlying placental ischemia, reflected by a hyperproliferative trophoblast, increased hCG secretion, and increased placental resistance may account for the maternal findings of Ballantyne syndrome.
ISSN:1057-0802
1520-6661
DOI:10.1002/(SICI)1520-6661(199809/10)7:5<227::AID-MFM3>3.0.CO;2-I