Metabolic effects of long-acting somatostatin analogue (sandostatin) in type I diabetic patients on conventional therapy
Metabolic effects of long-acting somatostatin analogue (sandostatin) in type I diabetic patients on conventional therapy. K Osei , T M O'Dorisio , W B Malarkey , E L Craig and S Cataland Department of Internal Medicine, Ohio State University Hospitals, Columbus. Abstract We evaluated the effect...
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Published in | Diabetes (New York, N.Y.) Vol. 38; no. 6; pp. 704 - 709 |
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Main Authors | , , , , |
Format | Journal Article |
Language | English |
Published |
American Diabetes Association
01.06.1989
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Online Access | Get full text |
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Summary: | Metabolic effects of long-acting somatostatin analogue (sandostatin) in type I diabetic patients on conventional therapy.
K Osei ,
T M O'Dorisio ,
W B Malarkey ,
E L Craig and
S Cataland
Department of Internal Medicine, Ohio State University Hospitals, Columbus.
Abstract
We evaluated the effectiveness of a more potent and longer-acting somatostatin analogue (SMS 201-995) as an adjunct to insulin
therapy, in a double-blind placebo-controlled randomized study of 26 C-peptide-negative type I (insulin-dependent) diabetic
patients (20 women, 6 men, aged 22-40 yr) on their conventional drug regimens for 12 wk. Eight patients received a low dose
(10 micrograms) of the analogue, 9 received a high dose (50 micrograms) of the analogue, and 9 received placebo subcutaneously
before breakfast and dinner. Twenty-four-hour serum glucose, free insulin, plasma growth hormone (GH), and glucagon profiles
were obtained before and during treatment at 4-wk intervals. The mean age, duration of diabetes, daily insulin dose, and body
weight were not significantly different among the groups. The mean weekly capillary blood glucose values and exogenous insulin
requirements were not changed by the SMS 201-995 therapy. Mean glycosylated hemoglobin A1 levels were unchanged in both the
analogue- and placebo-treated groups at wk 12. Basal and postprandial glucose, free insulin, GH, and glucagon profiles were
not influenced by the SMS 201-995 therapy throughout the study. Nocturnal glucose turnover rates (D-[3-3H]glucose technique)
remained unaltered by the analogue therapy. Dose-dependent gastrointestinal (GI) adverse effects (e.g., diarrhea) were documented
in the analogue-treated patients. Visual acuity and fundic photomicrographs of our patients were not changed by the analogue
therapy. In conclusion, the prominent adverse GI effects our patients experienced preclude the use of larger doses of the
analogue that may be necessary to suppress GH and glucagon and improve glucose control in type I diabetic patients. |
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ISSN: | 0012-1797 1939-327X 0012-1797 |
DOI: | 10.2337/diabetes.38.6.704 |