Visible-light-mediated direct C3-arylation of 2H-indazoles enabled by an electron-donor-acceptor complex

A mild visible-light-mediated, photocatalyst-free arylation of 2H-indazoles was developed. The formation of an electron donor-acceptor complex by 2H-indazoles and aryl diazonium salts in the presence of pyridine allows the direct arylation of 2H-indazoles under visible-light irradiation. This proces...

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Bibliographic Details
Published inOrganic & biomolecular chemistry Vol. 17; no. 45; pp. 9698 - 9702
Main Authors Aganda, Kim Christopher C., Kim, Junyoung, Lee, Anna
Format Journal Article
LanguageEnglish
Published CAMBRIDGE Royal Soc Chemistry 07.12.2019
Royal Society of Chemistry
Subjects
Aromatic compounds
Bioactive compounds
Chemistry
Chemistry, Organic
Coordination compounds
Irradiation
Light irradiation
NMR
Nuclear magnetic resonance
Physical Sciences
Pyridines
Radiation
Salts
Science & Technology
FUNCTIONALIZATION
ORGANIC-SYNTHESIS
DESIGN
ARYLATION
INDAZOLES
ARYL
INHIBITORS
CHARGE-TRANSFER
DISCOVERY
PHOTOREDOX CATALYSIS
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Summary:A mild visible-light-mediated, photocatalyst-free arylation of 2H-indazoles was developed. The formation of an electron donor-acceptor complex by 2H-indazoles and aryl diazonium salts in the presence of pyridine allows the direct arylation of 2H-indazoles under visible-light irradiation. This process provides an efficient route for the synthesis of C3-arylated-2H-indazoles, which are important scaffolds of various bioactive compounds.
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ISSN:1477-0520
1477-0539
DOI:10.1039/c9ob02074h