THE EFFECTIVENESS OF COMPLEX THERAPY WITH THE INCLUSION OF THE URSODEOXYCHOLIC ACID IN PATIENTS WITH NON-ALCOHOLIC FATTY LIVER DISEASE IN COMBINATION WITH CHRONIC OBSTRUCTIVE PULMONARY DISEASE

• Published in: Wiadomości lekarskie (1960) Vol. 74; no. 10 cz 2; p. 2575
• Main Authors: Khramtsova, Iryna O, Derbak, Maria A, Ganich, Taras M, Boldizhar, Oleksandr O, Lazur, Yana V
• Format: Journal Article
• Language: English
• Published: Poland 2021
• Subjects: Administration, Oral; Humans; Immunotherapy; Non-alcoholic Fatty Liver Disease - complications; Non-alcoholic Fatty Liver Disease - drug therapy; Pulmonary Disease, Chronic Obstructive - complications; Pulmonary Disease, Chronic Obstructive - drug therapy; Ursodeoxycholic Acid - therapeutic use; ademethionine; systemic inflammation; NAFLD; UDCA; COPD
• ISSN: 0043-5147
• DOI: 10.36740/wlek202110208

The aim: Was increase the effectiveness of treatment in patients with non-alcoholic fatty liver disease (NAFLD) comorbid with chronic obstructive pulmonary disease (COPD) by using ursodeoxycholic acid (UDCA) in combination with ademethionine. Materials and methods: Under observation was 98 patients with a diagnosis of NAFLD and COPD group II or their combination. Patients were divided into 3 groups: 1 (n = 36) - COPD + NASH - in addition to standard COPD therapy received UDCA 15 mg / kg / day - 6 months and ademethionine 1000 mg IV once a day for 10 days, followed by oral administration of 500 mg 2 times per day - 20 days, and group 2 (n = 32) - COPD + hepatic steatosis - in addition to standard therapy - UDCA 15 mg / kg / day - 6 months. Group 3 (n = 30) - COPD received standard therapy for COPD. Results: UDCA with ademethionine on the background of standard COPD therapy reduces the clinical manifestations of NAFLD and normalizes liver function. The combination of UDCA with ademethionine not only has a positive effect on the course of NAFLD, but also reduces the intensity of dyspnea, systemic inflammation, improves the external respiration function and reduces anxiety and depression. Patients receiving UDCA + ademethionine for 6 months of follow-up had no exacerbations of COPD. Conclusions: UDCA in combination with ademethionine in COPD courses have a positive effect on the course of NAFLD, and also reduces the intensity of dyspnea, improves the external respiratory function and reduces the frequency of COPD hospitalization.