The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats

The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats. D K Yue , M A Hanwell , P M Satchell and J R Turtle Abstract This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozo...

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Published inDiabetes (New York, N.Y.) Vol. 31; no. 9; pp. 789 - 794
Main Authors Yue, D. K., Hanwell, M. A., Satchell, P. M., Turtle, J. R.
Format Journal Article
LanguageEnglish
Published American Diabetes Association 01.09.1982
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Summary:The effect of aldose reductase inhibition on motor nerve conduction velocity in diabetic rats. D K Yue , M A Hanwell , P M Satchell and J R Turtle Abstract This study examined the effects of an aldose reductase inhibitor (CP 45634, Sorbinil, Pfizer, New York, New York) on the neuropathy of streptozotocin-induced diabetic rats. Sorbinil treatment for 4 wk reduced sciatic nerve sorbitol concentration and improved motor nerve conduction velocity in diabetes of 2-9 mo duration. It remains to be determined whether Sorbinil can prevent chronic diabetic neuropathy.
ISSN:0012-1797
1939-327X
0012-1797
DOI:10.2337/diabetes.31.9.789