Olanzapine differentially affects 5-HT2Aand2C receptor mRNA expression in the rat brain

• Published in: Behavioural brain research Vol. 171; no. 2; pp. 355 - 362
• Main Authors: Huang, Xu-Feng, Han, Mei, Huang, Xin, Zavitsanou, Katerina, Deng, Chao
• Format: Journal Article
• Language: English
• Published: Netherlands 10.08.2006
• Subjects: Analysis of Variance; Animals; Benzodiazepines - pharmacology; Brain - drug effects; Brain - metabolism; Down-Regulation - drug effects; Female; Gene Expression Regulation - drug effects; Random Allocation; Rats; Rats, Sprague-Dawley; Receptor, Serotonin, 5-HT2A - drug effects; Receptor, Serotonin, 5-HT2A - genetics; Receptor, Serotonin, 5-HT2A - metabolism; Receptor, Serotonin, 5-HT2C - drug effects; Receptor, Serotonin, 5-HT2C - genetics; Receptor, Serotonin, 5-HT2C - metabolism; RNA, Messenger - drug effects; RNA, Messenger - metabolism; Serotonin Uptake Inhibitors - pharmacology
• ISSN: 0166-4328
• DOI: 10.1016/j.bbr.2006.03.040

This study examined regional changes in rat brain mRNA levels encoding 5-HT(2A) and 5-HT(2C) receptors following chronic olanzapine treatment. The immediate effect (2h after the last treatment) was a down-regulation of 5-HT(2A) receptor mRNA expression, predominantly in the hypothalamus, limbic system and striatum, while a rebound effect was observed 48 h later. 5-HT(2C) receptor mRNA expressions were decreased in the substantia nigra. Correlations between 5-HT(2A) receptor mRNA expression and total food intake, weight gain and energy efficiency were observed.