Expression of p53 Protein in Prostate Carcinoma and its Correlation with Gleason Grade

• Published in: Journal of the College of Physicians and Surgeons--Pakistan Vol. 30; no. 6; pp. 643 - 645
• Main Authors: Wahid, Zakia, Jaffer, Rozina, Khalid, Sobia, Khan, Haseeb Ahmed, Riaz, Sabiha
• Format: Journal Article
• Language: English
• Published: Pakistan College of Physicians and Surgeons Pakistan 01.06.2020
• Subjects: Carcinoma; Care and treatment; Development and progression; Gene expression; Genetic aspects; Health aspects; Humans; Male; Neoplasm Grading; Prostate cancer; Prostatic Neoplasms; Tumor proteins; Tumor Suppressor Protein p53; Pakistan
• ISSN: 1022-386X; 1681-7168
• DOI: 10.29271/jcpsp.2020.06.643

To determine the correlation of p53 expression with Gleason score in prostate cancer. Descriptive study. Department of Pathology, Fatima Memorial Hospital, Lahore; from January 2014 to August 2016. Thirty-seven samples of prostate carcinoma were graded using Gleason grading system. p53 expression was detected through routine immunohistochemical staining protocols and assessed semi-quantitatively using four-point scale score. The collected data was analysed statistically using Pearson's correlation coefficient.   Results: Out of a sample of 37, high grade tumours were observed in 21 (57%) cases, making them the most prevalent type; while, p53 positive nuclear staining was observed in 26 (70%) cases. Within the high grade tumours, strong positive p53 expression was observed in 8 (38%) tumours; while, overexpression of p53 protein was seen in 7 (33%) cases. In contrast, overexpression of p53 was absent in low grade tumours. A statistically significant correlation was observed between p53 positive expression and high Gleason grade. Key Words: Prostate cancer, Immunohistochemistry, p53 protein, Gleason score.