Differences in the N-acetylneuraminic acid content of serum, urine and feces between breast-fed and formula-fed infants

• Published in: Nihon Eiyō, Shokuryō Gakkai shi Vol. 48; no. 1; pp. 43 - 48
• Main Authors: Idota, T. (Snow Brand Milk Products Co. Ltd., Kawagoe, Saitama (Japan). Technical Research Inst.), Sugawara, M, Nakajima, I, Ueda, A
• Format: Journal Article
• Language: Japanese
• Published: Japan Society of Nutrition and Food Science 1995
• Subjects: ALIMENTATION AU SEIN; BEBES; breast-fed infants; ENFANT EN BAS AGE; FECES; formula-fed infants; HECES; LACTANCIA MATERNA; LAIT DESHYDRATE; LECHE EN POLVO; NeuAc content in feces; NeuAc content in serum; NeuAc content in urine; ORINA; SERUM SANGUIN; SUERO SANGUINEO; URINE
• ISSN: 0287-3516; 1883-2849
• DOI: 10.4327/jsnfs.48.43

The content of N-acetylneuraminic acid (NeuAc) in serum, urine and feces from breast-fed and formula-fed infants at 2-7 days after delivery was determined. The serum content of NeuAc in breast-fed infants was 41.2 +- 8.58 mg/dl and that in formula-fed infants was 37.0 +- 5.45 mg/dl, the later being significantly lower (p0.05). The ratio of NeuAc to creatinine in urine of breasted-fed infants was 0.390 +- 0.079 and that of formula-fed infants was 0.294 +-0.081 (p0.05). The content of NeuAc in feces of breast-fed infants was NeuAc excreted into urine and feces was 18.6 mg/day and 45.9 mg/day in breast-fed infants, and 14.0 mg/day and 23.6 mg/day in formula-fed infants. High performance thin-layer chromatography revealed little 6'-sialyllactose in urine and feces of formula-fed infants. These differences may be because human milk contains more NeuAc than infant formula