Factor VIII inhibitors: in vivo decrease of inhibitory activity during calcium infusion

The effect of parenteral calcium on altering the activity of factor VIII inhibitors has been studied in three patients, two nonhemophiliacs and one hemophiliac. The patients were studied during both intravenous calcium infusion, factor VIII replacement, and combinations thereof. When compared to fac...

Full description

Saved in:
Bibliographic Details
Published inAmerican journal of hematology Vol. 20; no. 2; p. 107
Main Authors Muhleman, A F, Glueck, H I, Miller, M A, Coots, M
Format Journal Article
LanguageEnglish
Published United States 1985
Subjects
Blood Coagulation - drug effects
Calcium - administration & dosage
Factor VIII - antagonists & inhibitors
Female
Hemophilia A - blood
Humans
Infusions, Parenteral
Isoelectric Focusing
Male
Middle Aged
Partial Thromboplastin Time
Online AccessGet more information

Cover

More Information
Summary:The effect of parenteral calcium on altering the activity of factor VIII inhibitors has been studied in three patients, two nonhemophiliacs and one hemophiliac. The patients were studied during both intravenous calcium infusion, factor VIII replacement, and combinations thereof. When compared to factor VIII replacement alone, a greater diminution of inhibitory activity was noted whenever calcium was infused prior to and during factor VIII replacement. This was demonstrated by both conventional coagulation assays and an agarose gel method. These observations could have therapeutic implications and may aid in further understanding the relationship of calcium to factor VIII and its inhibitor.
ISSN:0361-8609
1096-8652
DOI:10.1002/ajh.2830200203