Measuring Dissipation of Molecular Motor Kinesin

Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. The nonequilibrium energetics of single molecule kinesin were investigated by measuring the motion of an attached probe particle and its response to external forces with optical tweezers. The sum of the...

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Bibliographic Details
Published inSeibutsu Butsuri Vol. 59; no. 6; pp. 300 - 304
Main Authors ARIGA, Takayuki, TOMISHIGE, Michio, MIZUNO, Daisuke
Format Journal Article
LanguageEnglish
Japanese
Published Suita The Biophysical Society of Japan General Incorporated Association 2019
Japan Science and Technology Agency
Subjects
Chemical energy
energetics
fluctuation dissipation theorem
Free energy
Kinesin
molecular motor
Molecular motors
nonequilibrium
Open systems
Organic chemistry
single molecule
Variation
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Summary:Molecular motors are nonequilibrium open systems that convert chemical energy to mechanical work. The nonequilibrium energetics of single molecule kinesin were investigated by measuring the motion of an attached probe particle and its response to external forces with optical tweezers. The sum of the heat dissipation estimated from the violation of the fluctuation-response relation and the output power was inconsistent with the input free energy rate, indicating that large internal dissipation exists. Here we introduce the theoretical basis of the dissipation measurement and our recent experimental results, discussing the physiological implications of the hidden dissipation in the kinesin motor.
ISSN:0582-4052
1347-4219
DOI:10.2142/biophys.59.300