Intradermal desensitization with human insulin (recombinant DNA) in a patient with severe allergic skin reaction due to insulin
This is a case report of a 70-yr-old female patient with a severe allergic skin reaction (necroses) due to insulin injections. Because of insulin dependency, desensitization to insulin was mandatory. For desensitization, a schedule with intradermal injections of increasing insulin concentrations (fr...
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Published in | Diabetes care Vol. 5 Suppl 2; no. Supplement_2; pp. 165 - 167 |
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Main Authors | , , |
Format | Journal Article |
Language | English |
Published |
United States
01.11.1982
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Subjects | |
Online Access | Get full text |
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Summary: | This is a case report of a 70-yr-old female patient with a severe allergic skin reaction (necroses) due to insulin injections. Because of insulin dependency, desensitization to insulin was mandatory. For desensitization, a schedule with intradermal injections of increasing insulin concentrations (from 0.02 to 2 U per injection) at time intervals of 3 h was used. With highly purified pork insulin, the concentration limit of 0.04 U was reached in spite of 75 injections. After changing to human insulin (recombinant DNA), a rapid desensitization could be performed at the same concentration. Desensitization resulted not only to human insulin but also to highly purified pork insulin, as shown by intradermal testing 6 mo later. |
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Bibliography: | ObjectType-Case Study-2 SourceType-Scholarly Journals-1 ObjectType-Feature-4 content type line 23 ObjectType-Report-1 ObjectType-Article-3 |
ISSN: | 0149-5992 1935-5548 |
DOI: | 10.2337/diacare.5.2.s165 |