Intradermal desensitization with human insulin (recombinant DNA) in a patient with severe allergic skin reaction due to insulin

This is a case report of a 70-yr-old female patient with a severe allergic skin reaction (necroses) due to insulin injections. Because of insulin dependency, desensitization to insulin was mandatory. For desensitization, a schedule with intradermal injections of increasing insulin concentrations (fr...

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Bibliographic Details
Published inDiabetes care Vol. 5 Suppl 2; no. Supplement_2; pp. 165 - 167
Main Authors Bachmann, W, Hasche, H, Mehnert, H
Format Journal Article
LanguageEnglish
Published United States 01.11.1982
Subjects
Aged
Desensitization, Immunologic
Diabetes Mellitus, Type 1 - complications
Diabetes Mellitus, Type 1 - immunology
Drug Hypersensitivity - therapy
Female
Humans
Insulin - adverse effects
Insulin - immunology
Recombinant Proteins - immunology
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Summary:This is a case report of a 70-yr-old female patient with a severe allergic skin reaction (necroses) due to insulin injections. Because of insulin dependency, desensitization to insulin was mandatory. For desensitization, a schedule with intradermal injections of increasing insulin concentrations (from 0.02 to 2 U per injection) at time intervals of 3 h was used. With highly purified pork insulin, the concentration limit of 0.04 U was reached in spite of 75 injections. After changing to human insulin (recombinant DNA), a rapid desensitization could be performed at the same concentration. Desensitization resulted not only to human insulin but also to highly purified pork insulin, as shown by intradermal testing 6 mo later.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
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ObjectType-Report-1
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ISSN:0149-5992
1935-5548
DOI:10.2337/diacare.5.2.s165