Cutting Edge: CCR9 Promotes CD8 + T Cell Recruitment to the Brain during Congenital Cytomegalovirus Infection

CD8 T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8 T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expres...

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Published inThe Journal of immunology (1950) Vol. 209; no. 12; pp. 2281 - 2286
Main Authors Hilt, Zachary T, Charles, Wisler, Cheng, Katarina E, Tabilas, Cybelle, Steinhilber, Megan, Wesnak, Samantha P, Smith, Norah L, Schaffer, Chris B, Rudd, Brian D
Format Journal Article
LanguageEnglish
Published United States 15.12.2022
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Summary:CD8 T lymphocytes infiltrate the brain during congenital CMV infection and promote viral clearance. However, the mechanisms by which CD8 T cells are recruited to the brain remain unclear. Using a mouse model of congenital CMV, we found a gut-homing chemokine receptor (CCR9) was preferentially expressed in CD8 T cells localized in the brain postinfection. In the absence of CCR9 or CCL25 (CCR9's ligand) expression, CD8 T cells failed to migrate to key sites of infection in the brain and protect the host from severe forms of disease. Interestingly, we found that expression of CCR9 on CD8 T cells was also responsible for spatial temporal positioning of T cells in the brain. Collectively, our data demonstrate that the CMV-infected brain uses a similar mechanism for CD8 T cell homing as the small intestine.
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ISSN:0022-1767
1550-6606
DOI:10.4049/jimmunol.2200578