Identification and quantitative determination of baclofen in human blood by HPLC with mass spectrometry detection

A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has b...

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Bibliographic Details
Published inBiomeditsinskaia khimiia Vol. 62; no. 3; p. 325
Main Authors Dukova, O A, Kotlovsky, M Yu, Pokrovsky, A A, Suvorova, E V, Shivrina, T G, Krasnov, E A, Efremov, A A
Format Journal Article
LanguageRussian
Published Russia (Federation) 01.03.2016
Subjects
Baclofen - blood
Baclofen - poisoning
Blood Chemical Analysis - methods
Case-Control Studies
Chromatography, High Pressure Liquid - methods
Humans
Mass Spectrometry - methods
Muscle Relaxants, Central - blood
Muscle Relaxants, Central - poisoning
Sensitivity and Specificity
diagnostics
HPLC-MS/MS
poisoning
baclofen
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Summary:A method of identification and quantitative determination of baclofen in blood by HPLC with mass spectrometry detection has been developed. It is characterized by high sensitivity, specificity, linearity, accuracy, reproducibility, and a low detection for quantitative determination. The method has been used for diagnostics of acute baclofen poisoning in patients.
ISSN:2310-6972
DOI:10.18097/PBMC20166203325