Potentiation of activation of soluble guanylate cyclase by YC-1, NO-donors and increase of the synergistic effect of YC-1 on NO-dependent activation of the enzyme by 1,2,3-triazolyl-1,2,5-oxadiazole derivatives

• Published in: Biomeditsinskaia khimiia Vol. 61; no. 6; p. 705
• Main Authors: Severina, I S, Pyatakova, N V, Shchegolev, A Yu, Rozhkov, V Yu, Batog, L V, Makhova, N N
• Format: Journal Article
• Language: Russian
• Published: Russia (Federation) 01.11.2015
• Subjects: Adult; Enzyme Activation; Guanylate Cyclase - chemistry; Humans; Male; Nitric Oxide - chemistry; Nitric Oxide Donors - chemistry; Oxadiazoles - chemistry; Receptors, Cytoplasmic and Nuclear - chemistry; Soluble Guanylyl Cyclase; nitric oxidt; soluble guanylate cyclase; YC-1; (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives
• ISSN: 2310-6972
• DOI: 10.18097/PBMC20156106705

The influence of (1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole derivatives: 4-amino-3-(5-methyl-4- ethoxycarbonyl-(1H-1,2,3-triazol-1-yl)-1,2,5-oxadiazole (TF4CH3) and 4,4'-bis(5-methel-4-ethoxycarbonyl-1H- 1,2,3-triazol-1-yl)-3,3'-azo-1,2,5-oxadiazole (2TF4CH3) on stimulation of human platelet soluble guanylate cyclase by YC-1, NO-donors (sodium nitroprusside, SNP, and spermine NONO) and on a synergistic increase of NO-dependent enzyme activation in the presence of YC-1 has been investigated. Both compounds increased guanylate cyclase activation by YC-1, potentiated guanylate cyclase stimulation by NO-donors and increased the synergistic effect of YC-1 on NO-dependent activation of soluble guanylate cyclase. The similarity in the properties of the examined TF4CH3 and 2TF4CH3 with that of YC-1 and the possible mechanism underlying the revealed properties of compounds used are discussed.