Skin type spiradenoma of the parotid gland with malignant transformation

Summary A distinctive variant of basal cell adenoma called membranous basal cell adenoma is well recognized in salivary glands. It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor. We present a case of a tumor involving the parotid gland that appeared identical to c...

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Bibliographic Details
Published inHuman pathology Vol. 40; no. 10; pp. 1499 - 1503
Main Authors Kazakov, Dmitry V., MD, PhD, Benkova, Kamila, MD, Michal, Michal, MD, Vanecek, Tomas, PhD, Kacerovska, Denisa, MD, PhD, Skalova, Alena, MD
Format Journal Article
LanguageEnglish
Published Elsevier Inc 2009
Subjects
Basal cell adenocarcinoma
CYLD gene
Dermal analogue tumor
Membranous basal cell adenoma
Parotid gland
Pathology
Spiradenocarcinoma
Spiradenoma
Basal cell adenocarcinoma
Spiradenoma
Parotid gland
Dermal analogue tumor
Membranous basal cell adenoma
Spiradenocarcinoma
CYLD gene
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Summary:Summary A distinctive variant of basal cell adenoma called membranous basal cell adenoma is well recognized in salivary glands. It appears identical to cutaneous cylindroma, hence the synonym dermal analogue tumor. We present a case of a tumor involving the parotid gland that appeared identical to cutaneous spiradenoma. In addition, the lesion had a malignant component identical to basal cell adenocarcinoma. The patient had no features suggestive of Brooke-Spiegler syndrome. Analysis of the CYLD gene revealed polymorphisms. This is the first report of a “dermal analogue tumor” of the salivary gland that resembled a cutaneous spiradenoma and not a cylindroma.
ISSN:0046-8177
1532-8392
DOI:10.1016/j.humpath.2009.02.015