Association of β1 and β3 adrenergic receptors gene polymorphisms with insulin resistance and high lipid profiles related to type 2 diabetes and metabolic syndrome

• Published in: Nutrición hospitalaria : organo oficial de la Sociedad Española de Nutrición Parenteral y Enteral Vol. 29; no. 6; pp. 1327 - 1334
• Main Authors: Burguete-Garcia, Ana I, Martinez-Nava, Gabriela A, Valladares-Salgado, Adan, Bermudez Morales, V H, Estrada-Velasco, Barbara, Wacher, Niels, Peralta-Romero, Jesus, Garcia-Mena, Jaime, Parra, Esteban, Cruz, Miguel
• Format: Journal Article
• Language: English; Portuguese
• Published: Spain Grupo Arán 01.06.2014; Arán Ediciones, S. L
• Subjects: Adult; Aged; Case-Control Studies; Diabetes; Diabetes Mellitus, Type 2 - epidemiology; Diabetes Mellitus, Type 2 - genetics; Diabetes Mellitus, Type 2 - metabolism; Female; Gene Frequency; Humans; Insulin Resistance - genetics; Male; Metabolic Syndrome - epidemiology; Metabolic Syndrome - genetics; Metabolic Syndrome - metabolism; Mexico - epidemiology; Middle Aged; Nutrition & Dietetics; Polymorphism, Genetic - genetics; Receptor adrenérgico; Receptors, Adrenergic, beta-1 - genetics; Receptors, Adrenergic, beta-3 - genetics; Síndrome metabólico; Type 2 diabetes; Receptor adrenérgico; Adrenergic receptors; Diabetes; Síndrome metabólico; Metabolic syndrome; Polymorphism
• ISSN: 1699-5198; 0212-1611; 1699-5198
• DOI: 10.3305/nh.2014.29.6.7367

Among the diverse genes associated to type 2 diabetes (T2D), the β-adrenergic receptors are an excellent candidate to study in Mexican population. The objective of this work was to analyze the association of polymorphisms in ADRB1 (rs1801253) (Arg389Gly) and ADRB3 (Trp64Arg) genes with T2D and metabolic syndrome (MS). We studied 445 MS patients, 502 with T2D and 552 healthy controls. Anthropometric features and complete biochemical profile were evaluated, and Arg389Gly and Trp64Arg SNPs were determined by TaqMan assays. Data analysis was adjusted by African, Caucasian and Amerindian ancestral percentage. The variant Arg389Gly of ADRB1 was statistically associated with an increase of LDL levels (P < 0.008), and the variant ADRB3 Trp64Arg was associated to larger HOMA-IR (P < 0.018) and with an increase of insulin levels (P < 0.001). A multiple logistic regression analysis was made in three grouping models: For ADRB3 in the codominant model Trp/Arg genotype, there was an OR of 1.53 (1.09-2.13, P < 0.003) which was increased up to OR 2.99 (1.44-6.22, P < 0.003) for the Arg/Arg genotype. Similar risk association was found under the dominant model Trp/Arg-Arg/Arg genotype with OR 1.67 (1.21-2.30; P < 0.002). In the recessive model (Arg/Arg genotype), there was also a high association OR 2.56 (1.24-5.26, P < 0.01). The ADRB3 Trp64Arg variant is a susceptibility gene polymorphism for T2D and the ADRB1 Gly389Arg for lipid metabolism disruption. These results show that these variants are potential biomarkers for predicting metabolic alterations and evolution in diabetic and metabolic syndrome patients.