QuatCy-I-2 and MHI-I-2 in Photodynamic Therapy

MHI-I-2 (1) and QuatCy-I-2 (2) were compared in terms of properties important for early-stage photodynamic therapy preclinical candidates. Thus, experiments were performed to monitor dark cytotoxicities, light/dark cytotoxicity ratios, selectivity of localization in tumors over other organs, and cle...

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Bibliographic Details
Published inACS medicinal chemistry letters Vol. 13; no. 3; pp. 470 - 474
Main Authors Thavornpradit, Sopida, Usama, Syed Muhammad, Park, G. Kate, Dinh, Jason, Choi, Hak Soo, Burgess, Kevin
Format Journal Article
LanguageEnglish
Published WASHINGTON Amer Chemical Soc 10.03.2022
Subjects
Chemistry, Medicinal
Life Sciences & Biomedicine
Pharmacology & Pharmacy
Science & Technology
DYE
near-infrared
fluorescence imaging
photodynamic therapy
tumor seeking
RESISTANCE
SENSITIZERS
MECHANISMS
heptamethine cyanine
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Summary:MHI-I-2 (1) and QuatCy-I-2 (2) were compared in terms of properties important for early-stage photodynamic therapy preclinical candidates. Thus, experiments were performed to monitor dark cytotoxicities, light/dark cytotoxicity ratios, selectivity of localization in tumors over other organs, and clearance from the plasma.
Bibliography:Federal RePORTER
ISSN:1948-5875
1948-5875
DOI:10.1021/acsmedchemlett.1c00640