40 Years Anniversary of Cardiac 123I-mIBG Imaging: State of the Heart

• Published in: Current cardiovascular imaging reports Vol. 14; no. 5
• Main Authors: Verschure, D. O., Nakajima, K., Jacobson, A. F., Verberne, H. J.
• Format: Journal Article
• Language: English
• Published: New York Springer US 2021; Springer Nature B.V
• Subjects: Cardiac Nuclear Imaging (A. Cuocolo and M. Petretta; Cardiology; Diagnostic Radiology; Imaging; Interventional Radiology; Medicine; Medicine & Public Health; Nuclear Medicine; Parameters; Radiology; Section Editors; Topical Collection on Cardiac Nuclear Imaging; Ultrasound; I; Prognosis; Chronic heart failure; Heart-to-mediastinum ratio; Washout; IBG scintigraphy
• ISSN: 1941-9066; 1941-9074
• DOI: 10.1007/s12410-021-09555-5

Purpose of Review This narrative review reflects on the body of evidence on cardiac 123 I- m IBG imaging that has accumulated since the introduction in the late 1970s and focusses on to what extent cardiac 123 I- m IBG imaging has fulfilled its potential in cardiology especially. Recent Findings In contrast to the linear relationship between 123 I- m IBG-derived parameters and overall prognosis in heart failure, there seems a “bell-shape” curve for 123 I- m IBG-derived parameters and arrhythmic events. In addition, there is a potential clinical role for cardiac 123 I- m IBG in optimizing patient selection for expensive devices (i.e., ICD and CRT). This needs of course to be established in future trials. Summary Cardiac 123 I- m IBG imaging is, despite the numerous of studies, sometimes mistakenly seen as a nice to have technique rather than a must have imaging modality. Although cardiac 123 I- m IBG imaging has grown and matured over the years, its full clinical potential has still not been tested to the maximum.