Synthesis and hyperpolarized 15N NMR studies of 15N-choline-d13

15N-Choline-d13 was synthesized as a new biomarker for dynamic nuclear polarization, and the lifetime of the polarized signal governed by the spin–lattice relaxation time T1 was measured. 15N-Choline-d13 exhibited a T1 that was over twice as long as that of 15N-choline, and the hyperpolarized 15N si...

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Published inTetrahedron Vol. 69; no. 19; pp. 3896 - 3900
Main Authors Kumagai, Keiko, Kawashima, Kazuyasu, Akakabe, Mai, Tsuda, Masayuki, Abe, Takamasa, Tsuda, Masashi
Format Journal Article
LanguageEnglish
Published Elsevier Ltd 01.05.2013
Subjects
Choline
Dynamic nuclear polarization
Choline
Dynamic nuclear polarization
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Summary:15N-Choline-d13 was synthesized as a new biomarker for dynamic nuclear polarization, and the lifetime of the polarized signal governed by the spin–lattice relaxation time T1 was measured. 15N-Choline-d13 exhibited a T1 that was over twice as long as that of 15N-choline, and the hyperpolarized 15N signal could be observed for 1 h. [Display omitted]
ISSN:0040-4020
1464-5416
DOI:10.1016/j.tet.2013.03.043