Therapeutic Strategies for SLE Involving Cytokines: Mechanism-Oriented Therapies Especially IFN- Targeting Gene Therapy

• Published in: BioMed research international Vol. 2010; pp. 1 - 19
• Main Author: Hayashi, Toshiharu
• Format: Journal Article
• Language: English
• Published: New York John Wiley & Sons, Inc 2010
• Subjects: Autoimmune diseases; Immune system; Lupus; Mutation

Systemic lupus erythematosus (SLE: lupus) is a chronic complicated autoimmune disease and pathogenesis is still unclear. However, key cytokines have been recognized. Interferon (IFN)- and also IFN are of particular importance. Depending on the concept that lupus is a helper T(Th)1 disease and that d...