Torsades-de-Pointes associated with Taku-Tsubo cardiomyopathy following greatly reduced oxycodone use in an elderly woman

This article reports an elderly female oxycodone consumer who developed Torsades-de-Pointes soon after her opioid-associated rate-corrected QT interval (QTC, a standard measurement on electrocardiograms) prolongation had been augmented by the development of Taku-Tsubo cardiomyopathy (TC), a sequence...

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Bibliographic Details
Published inJournal of opioid management Vol. 7; no. 2; p. 155
Main Author Daniell, Harry W
Format Journal Article
LanguageEnglish
Published United States 01.03.2011
Subjects
Aged
Aged, 80 and over
Analgesics, Opioid - adverse effects
Cardiomyopathies - chemically induced
Female
Humans
Long QT Syndrome - chemically induced
Oxycodone - adverse effects
Torsades de Pointes - chemically induced
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Summary:This article reports an elderly female oxycodone consumer who developed Torsades-de-Pointes soon after her opioid-associated rate-corrected QT interval (QTC, a standard measurement on electrocardiograms) prolongation had been augmented by the development of Taku-Tsubo cardiomyopathy (TC), a sequence that followed greatly reduced oxycodone ingestion. Factors that likely contributed to this sequence are discussed, including direct opioid-induced inhibition of human ether-a-go-go-related gene activity and of androgen formation plus QTc prolongation induced by the presence of TC.
ISSN:1551-7489
DOI:10.5055/jom.2011.0058