Cyclopentadienylcobalt-Mediated Intermolecular Cycloaddition of alpha,omega-Diynes to (Cyclo)alkenes: Synthesis of Linearly Fused Oligocycles and Extension to Enantiomerically Pure (6aR,10aR)-Dihydroanthracyclinones

The generality of the [CpCoL2]-mediated [2+2+2] cycloaddition of alpha,omega-diynes to (cyclo)alkenes has been extended to include linear oligocycles as models for the one-step, A + D -> ABCD construction of optically pure, novel 6,10-dihydroanthracyclinones.

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Bibliographic Details
Published inSynthesis (Stuttgart) no. 13; pp. 2179 - 2200
Main Authors Aubert, Corinne, Gandon, Vincent, Han, Sangdon, Johnson, Barry M., Malacria, Max, Schoemenauer, Sten, Vollhardt, K. Peter C., Whitener, Glenn D.
Format Journal Article
LanguageEnglish
Published STUTTGART Thieme Medical Publishers 01.07.2010
Subjects
Chemistry
Chemistry, Organic
Physical Sciences
Science & Technology
alkynes
transition metals
COMPLEXES
cycloadditions
alkenes
CATALYZED 2+2+2 CYCLOADDITION
N-H ACTIVATION
HINDERED ROTATION
COCYCLOTRIMERIZATION
CHEMISTRY
polycycles
C-H
COBALT
DIYNES
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Summary:The generality of the [CpCoL2]-mediated [2+2+2] cycloaddition of alpha,omega-diynes to (cyclo)alkenes has been extended to include linear oligocycles as models for the one-step, A + D -> ABCD construction of optically pure, novel 6,10-dihydroanthracyclinones.
Bibliography:National Science Foundation
ISSN:0039-7881
1437-210X
DOI:10.1055/s-0029-1220007