The effect of growth hormone on splanchnic glucose and substrate metabolism following oral glucose loading in healthy man
The effect of growth hormone on splanchnic glucose and substrate metabolism following oral glucose loading in healthy man. P R Bratusch-Marrain , S Gasić , W K Waldhäusl and P Nowotny Abstract Elevated plasma concentrations of growth hormone impair glucose tolerance and insulin sensitivity of periph...
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Published in | Diabetes (New York, N.Y.) Vol. 33; no. 1; pp. 19 - 25 |
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Main Authors | , , , |
Format | Journal Article |
Language | English |
Published |
American Diabetes Association
01.01.1984
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Online Access | Get full text |
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Summary: | The effect of growth hormone on splanchnic glucose and substrate metabolism following oral glucose loading in healthy man.
P R Bratusch-Marrain ,
S Gasić ,
W K Waldhäusl and
P Nowotny
Abstract
Elevated plasma concentrations of growth hormone impair glucose tolerance and insulin sensitivity of peripheral tissues. To
study the effect of short-term exposure to growth hormone concentrations elevated into the upper physiologic range (7-10 ng/ml)
on splanchnic carbohydrate metabolism, both splanchnic glucose output (SGO) and substrate exchange after ingestion of a 75-g
glucose load were determined by means of the liver vein catheter technique in six healthy volunteers after growth hormone
administration. Growth hormone was infused at a rate of 2 micrograms/kg X h starting 120 min before and continuing for 150
min following the glucose load. Control studies without growth hormone administration were performed in seven subjects. SGO
was 104 +/- 10 (SEM) mg/min in the postabsorptive state and increased to 43.4 +/- 2.2 g during the 150-min period following
glucose ingestion. Growth hormone infusion did not alter basal SGO (130 +/- 14 mg/min), nor the splanchnic exchange of lactate,
pyruvate, and free fatty acids, whereas basal production of beta-OH-butyrate was increased twofold; following glucose ingestion
a higher proportion of the given glucose load escaped the splanchnic bed after growth hormone exposure (66.9 +/- 6.8 g/150
min; P less than 0.005). The insulin production rate (basal 14 +/- 2 mU/min; following oral glucose 7.0 +/- 0.8 U/150 min)
as calculated from C-peptide release from the splanchnic area was unaltered by growth hormone exposure in the basal state
(14 +/- 3 mU/min), but augmented after glucose ingestion (14.8 +/- 1.5 U/150 min). |
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ISSN: | 0012-1797 1939-327X 0012-1797 |
DOI: | 10.2337/diabetes.33.1.19 |