In vitro specific cleavage of HIV-1 tat-RNA by catalytically active polyribonucleotide, ribozyme

The hammerhead type ribozyme-mediated cleavage of tat-RNA of human immunodeficiency virus type 1 data are presented. The ribozyme activity was appeared in magnesium-dependent manner at moderate temperature in the presence of monovalent cations and/or potyamines.

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Bibliographic Details
Published inBiopolimery i kletka Vol. 12; no. 2; pp. 20 - 23
Main Authors Buryanovsky, L. N., Schved, A. D.
Format Journal Article
LanguageEnglish
Published Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 1996
Subjects
Cations
HIV
Human immunodeficiency virus
Magnesium
Ribonucleic acid
RNA
RNA viruses
Tat protein
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Summary:The hammerhead type ribozyme-mediated cleavage of tat-RNA of human immunodeficiency virus type 1 data are presented. The ribozyme activity was appeared in magnesium-dependent manner at moderate temperature in the presence of monovalent cations and/or potyamines.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.00041B