The development of strategy for obtaining single-chain recombinant antibodies against cell-surface biomarkers on the example of human CD34

Antibodies against cell-surface proteins play an important role in cell detection, separation and determination of differentiation stage. The globular structure of extracellular region of cell-surface antigens is frequently characterized by heavily glycosilation and/or is stabilized by disulphide bo...

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Bibliographic Details
Published inBiopolimery i kletka Vol. 26; no. 6; pp. 492 - 498
Main Authors Nikolaiev, Iu. S., Gorbatiuk, O. B., Tsapenko, M. V.
Format Journal Article
LanguageEnglish
Published Kiev Natsional'na Akademiya Nauk Ukrainy - National Academy of Sciences of Ukraine 2010
Subjects
Antibodies
Antigens
CD34 antigen
Cell differentiation
Cell surface
Immunoglobulins
Surface antigens
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Summary:Antibodies against cell-surface proteins play an important role in cell detection, separation and determination of differentiation stage. The globular structure of extracellular region of cell-surface antigens is frequently characterized by heavily glycosilation and/or is stabilized by disulphide bonds. In this case the obtaining of antibodies against such proteins is a substantive problem.
ISSN:0233-7657
1993-6842
DOI:10.7124/bc.000179