Hemoglobin, Vitamin D, and Lipids in Subclinical Hypothyroid Patients – Do the Anti -Thyroid Autoantibodies Titer Matters?

Hashimoto's thyroiditis, the commonest cause of hypothyroidism has been proposed as a risk factor for atherosclerosis independent of thyroid function. The aim of this study was to investigate whether Hashimoto's thyroiditis validated by their anti-TPO positivity have any effect on hyperlip...

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Published inBiomedical & pharmacology journal Vol. 10; no. 3; pp. 1175 - 1180
Main Authors T, Jaseem, Hegde, Anupama, M., Chakrapani, Rao, Sathish
Format Journal Article
LanguageEnglish
Published Bhopal Biomedical and Pharmacology Journal 2017
Subjects
Anemia
Arteriosclerosis
Autoantibodies
Autoimmunity
Cardiovascular diseases
Cholesterol
Correlation analysis
Diabetes
Hashimoto's thyroiditis
Hemoglobin
Hyperlipidemia
Hypothyroidism
Inflammation
Lipids
Lipoproteins
Low density lipoprotein
Metabolism
Statistical analysis
Thyroid
Thyroid gland
Thyroid-stimulating hormone
Thyroiditis
Vitamin D
Womens health
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Summary:Hashimoto's thyroiditis, the commonest cause of hypothyroidism has been proposed as a risk factor for atherosclerosis independent of thyroid function. The aim of this study was to investigate whether Hashimoto's thyroiditis validated by their anti-TPO positivity have any effect on hyperlipidemia, Hemoglobin, vitamin D independent of thyroid function in newly diagnosed subclinical hypothyroid patients (SCH) subjects with TSH <10µiu/ml. 40 newly diagnosed sch and 40 healthy euthyroid controls were included in this study. based on anti-tpo status, the sch subjects was divided into tpo positive and negative groups. serum lipid, hemoglobin and vitamin d levels were determined and compared between among the tpo positive and negative sch subjects. subjects with and without anti-tpo had significant differences in levels of low-density lipoprotein, total cholesterol, and nonhdl cholesterol. in correlation analysis, anti-tpo showed statistically significant association with hb, ldl and vitamin d. subclinical hypothyroidism with thyroid autoimmunity is associated with a marginal decrease in hemoglobin and elevation in ldl. whether this holds, any bearing on promoting cardiovascular risk needs to be considered further
ISSN:0974-6242
2456-2610
DOI:10.13005/bpj/1218