Knowledge Discovery of Suppressive Effect of Disease and Increased Anti-oxidative Function by Low-dose Radiation Using Self-organizing Map

• Published in: RADIOISOTOPES Vol. 67; no. 2; pp. 43 - 57
• Main Authors: Kobashi, Yusuke, Ishida, Tsuyoshi, Kanzaki, Norie, Sakoda, Akihiro, Kataoka, Takahiro, Ishimori, Yuu, Yamaoka, Kiyonori, Yunoki, Yuto
• Format: Journal Article
• Language: English
• Published: Japan Radioisotope Association 15.02.2018
• Subjects: anti-oxidative function; low-dose radiation; radon therapy; self-organizing map
• ISSN: 0033-8303; 1884-4111
• DOI: 10.3769/radioisotopes.67.43

We previously reported that low-dose radiation induces the anti-oxidative function in many organ systems of mice. This results in the suppression of several kinds of oxidative stress-induced damage. However, to date, a proven cure has not been established. This study was conducted with the objective of revealing the health effects of low-dose radiation obtained from our previous reports and searching for a new treatment based on low-dose radiation, such as radon therapy. We extracted the characteristics of the effects of low dose radiation suppressing diseases and enhancing the anti-oxidative function using fuzzy answer by self-organizing map (SOM) based on mutual knowledge. The relationship between the suppressive effect and increased anti-oxidative function was shown in our result, and the concentration dependence of the effect against pain was shown on the output map. Although the effect against other organs depending on concentration was unpredictable, our results indicate that low-dose radiation may also be suitable for treatment of liver disease and brain disease. The results presented could encourage development and application of treatment using low-dose radiation, such as radon therapy.