6-Hydroxydopamine treatment increases beta-adrenoceptors and Ca2+ channels in rat heart

Rats received 6-hydroxydopamine (50 mg/kg i.v.) on two successive days. After 14 days cardiac beta-adrenoceptors and Ca2+ channels were measured by radioligand binding. Ca2+ channel binding [( 3H]nitrendipine) was increased 31% with no change in affinity, and beta-adrenoceptor binding [( 3H]dihydroa...

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Bibliographic Details
Published inEuropean journal of pharmacology Vol. 127; no. 3; p. 287
Main Authors Skattebøl, A, Triggle, D J
Format Journal Article
LanguageEnglish
Published Netherlands 15.08.1986
Subjects
Animals
Calcium - metabolism
Heart - drug effects
Heart - innervation
Hydroxydopamines - pharmacology
Ion Channels - analysis
Male
Myocardium - analysis
Oxidopamine
Rats
Receptors, Adrenergic, beta - analysis
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Summary:Rats received 6-hydroxydopamine (50 mg/kg i.v.) on two successive days. After 14 days cardiac beta-adrenoceptors and Ca2+ channels were measured by radioligand binding. Ca2+ channel binding [( 3H]nitrendipine) was increased 31% with no change in affinity, and beta-adrenoceptor binding [( 3H]dihydroalprenolol) was increased 28% with no change in affinity. Innervation may be important in the regulation of Ca2+ channel expression.
ISSN:0014-2999
DOI:10.1016/0014-2999(86)90378-X