Prevalence of oral manifestations in patients with lupus erythematosus in a sample of the Egyptian population: a hospital based cross-sectional study [version 1; peer review: 2 not approved]

• Published in: F1000 research Vol. 10; p. 969
• Main Authors: Saeed, Hager Moustafa, Mohammad Amr, Eman, Rezk Lotfy Rezk, Alshaimaa, Abd Elmoneim, Wesam
• Format: Journal Article
• Language: English
• Published: England 2021
• Subjects: Cross-Sectional Studies; Egypt - epidemiology; Female; Hospitals; Humans; Lupus Erythematosus, Systemic - complications; Lupus Erythematosus, Systemic - epidemiology; Male; Prevalence; Quality of Life; Egypt; precancerous oral lesions; lupus erythematosus; SLE; oral manifestations
• ISSN: 2046-1402; 2046-1402
• DOI: 10.12688/f1000research.55332.1

Background: Several systemic diseases manifest themselves in the oral cavity. Oral manifestations of lupus erythematosus (LE) are associated with a significantly increased risk of cancer. Dentists who are unaware of these lesions will possibly miss them. This cross-sectional study aimed to assess the prevalence of oral manifestations in patients with LE in a sample of the Egyptian population. Methods: A descriptive study was performed on 189 patients attending the Internal Medicine Department, Rheumatology Clinic in EL Qasr EL Ainy Hospital, Cairo University. Every patient was examined clinically after completing a questionnaire. Moreover, patients' medical records were also evaluated.  The oral manifestations were recorded according to the WHO guide to physical examination of the oral cavity and classified according to their morphologic aspects and localization. Results: Out of 189 patients, there were 182 females (96.3%) and seven males (3.7%). The prevalence of oral lesions in LE patients was 55.6%. The most affected site was the tongue 25.7%. The most common clinical aspect was patches, 53%. About 77.1% of the lesions were asymptomatic. 74.3% of the patients had oral candidiasis. The prevalence of skin lesions in LE patients was 37.6%. The most common finding was malar rash 79%. Conclusions: The present study emphasizes the importance of early diagnosis of oral lesions to recognize patients with LE as the WHO considers oral manifestations of LE a widespread state associated with an increased risk of cancer. Also, implementation of oral hygiene measures and treatment to improve patients' nutritional state and health-related quality of life are recommended.