CYP1A1 2B and 4 polymorphisms are associated with lung cancer susceptibility in Mexican patients

• Published in: The International journal of biological markers Vol. 23; no. 1; pp. 24 - 30
• Main Authors: Gallegos-Arreola, M P, Figuera-Villanueva, L E, Troyo-Sanroman, R, Morgn-Villela, G, Puebla-Prez, A M, Flores-Marquez, M R, Zniga-Gonzlez, G M
• Format: Journal Article
• Language: English
• Published: United States 01.01.2008
• ISSN: 0393-6155; 1724-6008
• DOI: 10.5301/JBM.2008.379

CYP1A1 is a gene involved in the high aryl hydrocarbon hydroxylase -inducible phenotype, which is a genetically-determined variation among individuals that has been associated with lung cancer risk. More specifically, CYP1A1*2B and *4 polymorphisms have been associated with high susceptibility to lung cancer among cigarette smokers. DNA was obtained from blood samples and we studied by PCR-RFLP the distribution of CYP1A1*2B (n=248) and *4 (n=222) polymorphisms in healthy controls and 222 lung cancer patients from a Mexican population. Comparisons between groups showed an increased risk for lung cancer patients of *2B/*2B (18%; OR 7.6; 95% CI 3.0-19.2) and *4/*4 genotypes (15%; OR 11.45; 95% CI 2.19-59.85) compared to the control group (1% for *2B/*2B and 4.4% for *4/*4). A significant association between lung cancer and homozygous *2B/*2B passive smokers and *4/*4 ever (cigarettes) and passive smokers was also observed (p<0.05). Multivariate analysis revealed an increased risk for the *2B/2B genotype (OR 6.83), as well as for *4/*4 (OR 28.8). The results of the study indicate a significant association between *2B/*2B and *4/*4 genotypes and the risk of developing lung cancer among Mexicans.