Biochemical Analysis by Calcium Determination on the Newly Formed Bone in Critical Bone Defects Submitted to Different Treatments: A Pilot Study

The aim of this study was to evaluate the calcium dosage of the newly formed bone, in critical bone defects created on the calvarial tissue and filled by different substances, in male Wistar rats. A cylindrical critical bone defect (6x2mm) was created in the posterior portion, left side, on the calv...

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Published inInternational journal of morphology Vol. 25; no. 3; pp. 511 - 518
Main Authors Issa, Joao Paulo Mardegan, Petenusci, Sergio Olavo, Siéssere, Selma, Regalo, Simone Cecilio Hallak, Lopes, Ruberval Armando, Di Matteo, Miguel Ángel Sala, Iyomasa, Mamie Mizusaki, Defino, Helton Luiz Aparecido
Format Journal Article
LanguageEnglish
Portuguese
Published Sociedad Chilena de Anatomía 01.09.2007
Subjects
ANATOMY & MORPHOLOGY
rhBMP-2
Carriers
Biomateriales
Reparación ósea
Calcium
Calcio
Transportadores
Bone repair
Biomaterials
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Summary:The aim of this study was to evaluate the calcium dosage of the newly formed bone, in critical bone defects created on the calvarial tissue and filled by different substances, in male Wistar rats. A cylindrical critical bone defect (6x2mm) was created in the posterior portion, left side, on the calvarial bone in nine animals and filled with: animals' coagulum, monoolein gel, poloxamer gel, monoolein gel + 1µg rhBMP-2, monoolein gel + 3µg rhBMP-2, monoolein gel + 7µg rhBMP-2, poloxamer gel + 1µg rhBMP-2, poloxamer gel + 3µg rhBMP-2, poloxamer gel + 7µg rhBMP-2. The results of this study showed a positive correlation between the calcium dosage analysis and the newly formed bone
ISSN:0717-9502
0717-9502
DOI:10.4067/S0717-95022007000300006