Rottlerin suppresses growth of human pancreatic tumors in nude mice, and pancreatic cancer cells isolated from KrasG12D mice

Highlights • Rottlerin inhibits pancreatic cancer tumor growth in nude mice. • Rottlerin inhibits pancreatic cancer cell growth isolated from KrasG12D mice. • Rottlerin exerts its effects by inhibiting Akt, Notch and Shh pathways. • Rottlerin can be used for the treatment of pancreatic cancer....

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Bibliographic Details
Published inCancer letters Vol. 353; no. 1; pp. 32 - 40
Main Authors Huang, Minzhao, Tang, Su-Ni, Upadhyay, Ghanshyam, Marsh, Justin L, Jackman, Christopher P, Srivastava, Rakesh K, Shankar, Sharmila
Format Journal Article
LanguageEnglish
Published Elsevier Ireland Ltd 10.10.2014
Subjects
Akt
Cancer prevention
Hematology, Oncology and Palliative Medicine
Notch
Pancreatic cancer
Rottlerin
Sonic Hedgehog
Cancer prevention
Akt
Rottlerin
Pancreatic cancer
Sonic Hedgehog
Notch
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Summary:Highlights • Rottlerin inhibits pancreatic cancer tumor growth in nude mice. • Rottlerin inhibits pancreatic cancer cell growth isolated from KrasG12D mice. • Rottlerin exerts its effects by inhibiting Akt, Notch and Shh pathways. • Rottlerin can be used for the treatment of pancreatic cancer.
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2014.06.021