Head and Neck Cancer: Proteomic Advances and Biomarker Achievements

• Published in: Cancer Vol. 116; no. 21; pp. 4914 - 4925
• Main Authors: BERTO REZENDE, Taia Maria, DE SOUZA FREIRE, Mirna, FRANCO, Octávio Luiz
• Format: Journal Article
• Language: English
• Published: Hoboken, NJ Wiley-Blackwell 01.11.2010
• Subjects: Biological and medical sciences; Biomarkers, Tumor - analysis; Biomarkers, Tumor - blood; Head and Neck Neoplasms - diagnosis; Head and Neck Neoplasms - epidemiology; Humans; Medical sciences; Neoplasms, Squamous Cell - diagnosis; Neoplasms, Squamous Cell - epidemiology; Otorhinolaryngology (head neck, general aspects and miscellaneous); Otorhinolaryngology. Stomatology; Proteomics - methods; Risk Factors; Tumors; Pathogenesis; diagnostic biomarkers; Biological marker; cancer pathogenesis; Malignant tumor; cancer risk factors; Epidemiology; Cancerology; Risk factor; Proteomics; ENT disease; Head and neck cancer; Diagnosis; Cancer
• ISSN: 0008-543X; 1097-0142
• DOI: 10.1002/cncr.25245

Tumors of the head and neck comprise an important neoplasia group, the incidence of which is increasing in many parts of the world. Recent advances in diagnostic and therapeutic techniques for these lesions have yielded novel molecular targets, uncovered signal pathway dominance, and advanced early cancer detection. Proteomics is a powerful tool for investigating the distribution of proteins and small molecules within biological systems through the analysis of different types of samples. The proteomic profiles of different types of cancer have been studied, and this has provided remarkable advances in cancer understanding. This review covers recent advances for head and neck cancer; it encompasses the risk factors, pathogenesis, proteomic tools that can help in understanding cancer, and new proteomic findings in this type of cancer.