Activation of epidermal growth factor receptor/insulin-like growth factor 1 receptor-β-Catenin-CD44 pathway in periampullary cancer

• Published in: Journal of Radiation and Cancer Research Vol. 11; no. 4; pp. 150 - 156
• Main Authors: Bankura, Biswabandhu, Maji, Suvendu, Chakraborty, Balarko, Alam, Neyaz, Panda, Chinmay
• Format: Journal Article
• Language: English
• Published: Wolters Kluwer India Pvt. Ltd 01.01.2020; Wolters Kluwer Medknow Publications
• Subjects: beta-catenin; cd44; epidermal growth factor receptor; insulin-like growth factor 1 receptor; periampullary cancer; insulin-like growth factor 1 receptor; periampullary cancer; Beta-catenin; epidermal growth factor receptor; CD44
• ISSN: 2588-9273; 2468-9203
• DOI: 10.4103/jrcr.jrcr_54_20

Background: Periampullary cancer (PC) is a global medical burden. Less than 5% of patients experience an overall survival of 5 years or more. The study aims to analyze the importance of epidermal growth factor receptor (EGFR)/insulin-like growth factor 1 receptor (IGF1R)-beta-catenin (β-catenin)-CD44 pathway in the development of periampullary cancer of Indian patients. Subjects and Methods: Expression profile of EGFR, IGF1R, β-catenin, and CD44 was verified by immunohistochemical analysis in primary tumor samples (N = 14) and respective adjacent normal tissues. Results: In periampullary carcinoma patients, a high level of EGFR expression was seen in 64% of the samples along with co-expression of IGF1R in 77.8% of samples. Furthermore, the high expression of EGFR and IGF1R significantly correlated with the increased expression of β-catenin along with CD44 expression of the tumors. Conclusion: The EGFR/IGF1R-β-catenin-CD44 pathway seems to be important in the development of PC with clinical importance.