Role of the TLR/MyD88 pathway in the modulation of the immune system activation mediated by Lactobacillus casei CRL 431

Lactobacillus casei (L. casei) CRL431 not only exerted activation of the innate immunity in the gut but also had effect in the systemic immunity response with enhanced of the phagocytic activity of peritoneal macrophages. Previous studies demonstrated that TLR, mainly TLR2, are involved in the intes...

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Bibliographic Details
Published inProceedings of the Nutrition Society Vol. 72; no. OCE1
Main Authors Maldonado-Galdeano, C., Perdigón, G., Thieblemont, N.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 2013
Subjects
Activation
Drinking water
Immune system
Immunity
Innate immunity
Intestine
Lactobacilli
Lactobacillus casei
Macrophages
Microbiota
Microorganisms
MyD88 protein
Peritoneum
Phagocytes
Phagocytosis
Probiotics
Proteins
TLR2 protein
TLR4 protein
Toll-like receptors
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Summary:Lactobacillus casei (L. casei) CRL431 not only exerted activation of the innate immunity in the gut but also had effect in the systemic immunity response with enhanced of the phagocytic activity of peritoneal macrophages. Previous studies demonstrated that TLR, mainly TLR2, are involved in the intestinal signals initiated when probiotic bacteria were administrated to conventional mice in the drinking water(7). According to the results obtained in the ex vivo assays showed that TLR2, TLR4 and the adaptor molecules MYD88 were involved in the phagocytic process of probiotics and the phagocytosis and the probiotic administration could not improve the macrophages phagocytic activity.
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665113000608