Human Leukocyte Antigen Alleles (HLA-A, HLA-B, and HLA-DRB1) are associated with Acute Lymphoblastic Leukemia (ALL) : A Case-Control Study in a Sample of Iranian Population

• Published in: Asian Pacific journal of cancer prevention : APJCP Vol. 25; no. 5; pp. 1507 - 1513
• Main Authors: Kohansal Vajari, Mahdi, Ehsan, Mohsen, Ghiasi, Saeedeh, Fooladi, Saba, Karami, Najibe, Hassanshahi, Gholamhossein, Fatemi, Ahmad
• Format: Journal Article
• Language: English
• Published: Thailand West Asia Organization for Cancer Prevention 01.05.2024
• Subjects: Adolescent; Adult; Alleles; Biomarkers, Tumor - genetics; Case-Control Studies; Child; Child, Preschool; Female; Follow-Up Studies; Genetic Predisposition to Disease; Genotype; HLA-A Antigens - genetics; HLA-B Antigens - genetics; HLA-DRB1 Chains - genetics; Humans; Iran - epidemiology; Male; Precursor Cell Lymphoblastic Leukemia-Lymphoma - genetics; Prognosis; Young Adult; Iran; PCR-SSP; Iranian population; HLA Alleles; Acute Lymphoblastic Leukemia
• ISSN: 1513-7368; 2476-762X
• DOI: 10.31557/APJCP.2024.25.5.1507

This study seeks to elucidate the association between HLA-A, HLA-B, and HLA-DRB1 alleles and their relative risk contributions to ALL within an Iranian cohort. Utilizing a robust case-control design, this research involved 71 ALL patients and 71 age and sex-matched healthy individuals. Genotyping of specified HLA alleles was performed using the advanced PCR-SSP technique. Our findings reveal a marked increase in the prevalence of the HLA-DRB1*04 allele among patients diagnosed with ALL compared to the control group (P<0.027). Conversely, the alleles HLA-A*26 (P=0.025), HLA-A*33 (P=0.020), and HLA-DRB1*03 (P=0.035) were observed at significantly reduced frequencies within the patient population. Our findings highlight HLA-DRB1*04 as a potential genetic marker for increased susceptibility to ALL, while HLA-A*26, HLA-A*33, and HLA-DRB1*03 emerge as protective factors.