The impact of intermittent energy restriction and mastication on hippocampal cognitive ageing and neural stem cell fate: the change study – chewing, adult neurogenesis and energy restriction

IER led to a reduction in weight compared to control (−2.85 kg, 95% CI [−4.12, −1.05], P < 0.001). [...]IER in combination with mastication led to reductions in saturated fat intake compared to control (−8.21 g/day, 95% CI [15.53, −0.89], P = 0.019) and free sugar intake compared to mastication o...

Full description

Saved in:
Bibliographic Details
Published inProceedings of the Nutrition Society Vol. 81; no. OCE1
Main Authors Kim, C., D'Annibale, M., Benoiton, B., Izmi, N.M., Danaher, O., Taylor, C., Baptista, M., Butt, H., Zaini, M., Bachi, H., Hall, W.L., Thuret, S.
Format Journal Article
LanguageEnglish
Published Cambridge, UK Cambridge University Press 2022
Subjects
Aging
Cell fate
Cognition
Cognition & reasoning
Cognitive ability
Folic acid
Hippocampus
Intervention
Klotho protein
Mastication
Memory
Micronutrients
Neural stem cells
Neurogenesis
Selenium
Stem cells
Vitamin E
Weight reduction
Online AccessGet full text

Cover

More Information
Summary:IER led to a reduction in weight compared to control (−2.85 kg, 95% CI [−4.12, −1.05], P < 0.001). [...]IER in combination with mastication led to reductions in saturated fat intake compared to control (−8.21 g/day, 95% CI [15.53, −0.89], P = 0.019) and free sugar intake compared to mastication only (−12.55 g/day, 95% CI [−24.17, −0.92], P = 0.027) possibly explaining the observed cognitive improvements. [...]greater baseline consumption of folate, vitamin E and selenium were associated with increased survival of proliferating HPCs. [...]IER and mastication may benefit the ageing-sensitive hippocampus dependent cognition in ageing humans. [...]preliminary results suggest that specific micronutrients and the anti- ageing protein Klotho are related to the human neurogenic process.
ISSN:0029-6651
1475-2719
DOI:10.1017/S0029665122000167