Generalized bullous fixed drug eruption induced by chlordiazepoxide: a case report of a potentially lethal adverse effect

BACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involve...

Full description

Saved in:
Bibliographic Details
Published inConsortium psychiatricum (English ed. Online) Vol. 6; no. 1; pp. 30 - 36
Main Authors Singh, Rishabh, Sudhanshu, Vaibhav Kumar, Shafiq, Mariam, Sharma, Markanday
Format Journal Article
LanguageEnglish
Published Eco-Vector 01.04.2025
Subjects
adverse effect
alcohol withdrawal
benzodiazepines
case report
chlordiazepoxide
generalized bullous fixed drug eruption
Online AccessGet full text

Cover

More Information
Summary:BACKGROUND: Fixed drug eruption is a type of adverse drug reaction affecting the skin, marked by recurrent rashes that appear at the same site each time a particular drug is taken. Generalized bullous fixed drug eruption (GBFDE) is a severe form of FDE characterized by vesicles or bullae and involvement of a significant portion of the body surface area. To date, no association between GBFDE and chlordiazepoxide has been reported in the literature. CASE REPORT: The authors present the case of a 40-year-old male inpatient in the psychiatry department of a tertiary care hospital in Assam, India. The patient was admitted in an alcohol withdrawal state and was initially prescribed chlordiazepoxide at a dose of 60 mg/day. He developed GBFDE within a day of chlordiazepoxide administration. The drug was discontinued, and he was treated with oral and topical corticosteroids instead, resulting in a significant improvement. CONCLUSION: Сhlordiazepoxide is a rare but potential trigger of GBFDE. Clinicians should closely monitor patients on chlordiazepoxide for possible signs of GBFDE.
ISSN:2712-7672
2713-2919
DOI:10.17816/CP15563