Discrete laboratory and morphometric markers of atherosclerotic lesions of lower extremity vessels

• Published in: Wiadomości lekarskie (1960) Vol. 73; no. 3; p. 561
• Main Authors: Horlenko, Olesya M, Studenyak, Viktoriya M, Horlenko, Fedir V, Prylypko, Lyubomyra B
• Format: Journal Article
• Language: English
• Published: Poland 2020
• Subjects: Atherosclerosis; Endothelial Cells; Folic Acid; Humans; Hyperhomocysteinemia; Lower Extremity; Middle Aged; endothelium; hyperhomocysteinemia; morphometry; obliterating atherosclerosis of lower extremity vessels; patients
• ISSN: 0043-5147
• DOI: 10.36740/WLek202003130

The aim: To investigate discrete laboratory and morphometric features of atherosclerotic lesions in patients with chronic ischemia of the lower extremities (CILE). Materials and methods:The examined contingent consisted of 47 patients (age 56.32 ± 1.09 years) diagnosed with obliterating atherosclerosis of the lower extremities. The study included determination of levels of Homocysteine, Folic acid, C protein, quantitative determination of circulating Endothelial cells (DEC) in blood plasma, and morphometric study of DEC. Results: Protein C levels are within the reference values (0.97 ± 0.12 mg / l. In 37 (78.7%) patients Hypoacidofoliemia (<3.0 mmol / l) was observed. Homocysteine levels were clearly elevated in all patients. In the vast majority Hyperhomocysteinemia mild form (91.5%) was observed. The number of DEC in patients was -3.22 ± 0.39x105/l and after compression -6.12 ± 0.21x105/l. Conclusions: Protein C levels were within the reference values (0.97 ± 0.12 mg / l); Folic acid levels in the vast majority (37 patients, 78.7%) were <3.0 mmol /l. Blood plasma Homocysteine levels were clearly elevated in all patients. The mild form of Hyperhomocysteinemia (91.5%). was observed in the vast majority The number of DEC in patients was -3.22 ± 0.39x105 and after compression -6.12 ± 0.21x105/l, which confirmed the presence of the endothelial dysfunction.